Background Partner of Sld five 3 (Psf3) is an associate of the heterotetrameric complex that consists of SLD5, Psf1, Psf2, and Psf3. of Psf3 was observed in 211 (36.2%) and low expression of Psf3 observed in 372 (63.8%) patients. Among stage I patients, the five\12 months survival rate was 76.7% in the Psf3 high expression group and 90.9% in the Psf3 low expression group (= 0.873). Conclusion The Psf3 expression was an independent prognostic factor and could be a biomarker of adjuvant tegafur\uracil for stage I pulmonary adenocarcinoma. Key points Significant findings of the study: The Psf3 expression could be a biomarker of adjuvant tegafur\uracil (R)-MIK665 administration for stage I pulmonary adenocarcinoma. What this study adds: Appropriate patients of adjuvant chemotherapy for stage I pulmonary adenocarcinoma using Psf3 expression could be selected. = 583) = 0.0876; Fig ?Fig11c). Open in a separate window Physique 1 (a) Survival curve in patients with stage I pulmonary adenocarcinoma (=?583), () Psf3 low positive (= 372) and () Psf3 high positive (= 211), (b) Survival curve in patients with stage IA pulmonary adenocarcinoma according to Psf3 expression (=?398), () Psf3 low positive (= 275) and () Psf3 high positive (= 123), and (c) Survival curve in patients with stage IB pulmonary adenocarcinoma, according to Psf3 expression among stage IB patients (=?185). () Psf3 low positive (= 97) and () Psf3 high positive (= 88). Among stage I patients, the five\12 months recurrence\free survival (RFS) rate was significantly lower in the Psf3 high expression group than in the Psf3 low expression group (72.5% vs. 88.7%, =?583), () Psf3 low positive (= 372) and () Psf3 high positive (= 211), (b) Recurrence\free survival curve in patients with stage IA pulmonary adenocarcinoma (=?398), () Psf3 low positive (= 275) and () Psf3 high positive (= 123), and (c) Recurrence\free survival curve in patients with stage IB pulmonary adenocarcinoma, according to Psf3 expression among stage IB patients (=?185). () Psf3 low positive (= 97) and () Psf3 high positive (= 88). Table 2 Univariate analysis of the association between overall survival and prognostic factors in stage I pulmonary adenocarcinoma by the Cox proportional hazards model (= 583) = 583) = 0.873; Fig ?Fig4a);4a); a similar outcome was observed among patients in stage IA (92.9% and 94.7%, respectively; = 0.924; Fig ?Fig4b).4b). However, among Psf3 low expression patients in stage IB, the five\12 months survival was significantly higher in patients who Rabbit Polyclonal to MASTL underwent surgery with adjuvant UFT than in those who underwent surgery alone (90.0% vs. 73.7%, = 0.0137; Fig ?Fig44c). Open in a separate window Physique 3 (a) Survival curve among patients with stage I pulmonary adenocarcinoma with high\positive Psf3 expression and who received adjuvant UFT (=?211). () Surgery?+?UFT (= 59) and () surgery alone (= 152). (b) Survival curve among patients with stage IA pulmonary adenocarcinoma with (R)-MIK665 high expression of Psf3 and who received adjuvant UFT (=?123). () Surgery?+?UFT (= 28) and () surgery alone (= 95). (c) Survival curve among patients with stage IB pulmonary adenocarcinoma with high expression of Psf3 and who received adjuvant UFT (=?88). () Surgery?+?UFT (= 31) and () surgery alone (= 57). UFT, tegafur\uracil. Open in a separate window Physique 4 (a) Survival curve among patients with stage I pulmonary adenocarcinoma with low expression of Psf3 and who received adjuvant UFT (=?372). () Surgery?+?UFT (= 68) and () surgery alone (=?304). (b) Survival curve among patients with stage I pulmonary adenocarcinoma with low expression of Psf3 and who received adjuvant UFT (=?275). () Surgery?+?UFT (= 28) and () surgery alone (= 247). (c) Survival curve among patients with stage IB pulmonary (R)-MIK665 adenocarcinoma with low expression of Psf3 and who received adjuvant UFT (=?97). () Surgery?+?UFT (= 40) and () surgery alone (= 57). UFT, tegafur\uracil. Discussion In this scholarly study, we confirmed that high appearance of Psf3 was an unhealthy prognostic aspect among sufferers with stage I pulmonary adenocarcinoma. Furthermore, the efficiency of UFT as adjuvant chemotherapy was proven for both stage IA and IB sufferers with high appearance of Psf3 but not in stage IA patients with low expression of Psf3. According to previous reports in Japan, adjuvant UFT can be utilized for stage I patients with tumor diameter??2 cm, but its efficacy had not been reported for stage IA patients with tumor diameter?