Since 2019 December, a respiratory pandemic named as coronavirus disease 2019 (Covid-19) the effect of a fresh coronavirus named as SARS-CoV-2, has taken the entire world by surprise. importance, (i) purification of environment using certain natural medicines as fumigants or sprays, (ii) wellness AKT2 advertising and immune-modulation, and (iii) use of health-protecting drugs and symptom-specific drugs. Drugs such as (W. G. Craib), (Gaertn.) (L.), vinegar etc. are prescribed in various forms. Scientific researches on these drugs reveal the presence of a number of pharmacologically active substances, which may provide a new insight into the management of infections and epidemics. (The Law in Medicine) of Ibn Sina (980C1035?CE), (The Comprehensive Book of Medicine) of Zakariya Razi (865C925?CE), (The Complete Book on Medicine) by Ibn Rushd (1126C1198?CE), (Book dedicated to Caliph Mansoor) by (865C925?CE), and (The Book on Choice of Medicine) by Ibn Hubal Baghdadi (1121C1213?CE). Other published books and journals were also consulted for further details. For information on SARS-CoV-2 and Covid-19, we searched major scientific databases namely Pubmed, Science Direct and Springer for the most recent information regarding the pandemic. The search words used were SARS-CoV-2, Covid-19, history, prevalence, symptoms, and transmission. Internet search on the same search engines and also Google Scholar was also done to search for scientific evidence regarding Unani drugs prescribed during epidemics. For this search, we used the terms air purification, influenza, epidemic, immunomodulatory, and bioactive compounds along with the names of drugs, according to their use. Time restriction was not made to extract the most useful information. The articles published during 2005C2020 were hence included in the final manuscript. 3.?Coronavirus disease 2019 3.1. (+) PD 128907 Causative agent SARS-CoV-2 is a coronavirus belonging to the genus -coronaviruses, sub-genus botulinum (Sun et al., 2020). It is the seventh in the family of coronaviruses which is known to infect humans (Andersen et al., 2020). Coronaviruses are a group of enveloped viruses with a spherical shape, having a non-segmented, single-stranded RNA genome with club-like (+) PD 128907 projecting spikes on their surface (Phan, 2020a). SARS-CoV-2 was first isolated from bronchoalveolar lavage samples from three patients suffering from pneumonia of unidentified cause (Zhu et al., 2020). Structurally, the genome of SARS-CoV-2 is similar to other -coronaviruses. It has a long coding strand on which five ORFs are (+) PD 128907 identified: including ORF1ab polyprotein, spike (S) glycoprotein, envelope protein, membrane protein, and nucleocapsid protein (Phan, 2020a). The S glycoprotein is the primary target of antibodies and vaccines as it is surface-exposed (Walls et al., 2020). Two distinct features have been determined within the genome series: (i) Structural and biochemical research have determined that SARS-CoV-2 receptor-binding site (RBD) within the spike proteins includes a high affinity to human being or human-like angiotensin switching enzyme-2 (ACE2) receptors; and (ii) another feature is really a polybasic cleavage in the junction of sub-units S1 and S2 from the spike, which might determine the infectivity and sponsor selection of the pathogen (Andersen et al., 2020). Mutations and deletions are also determined within the genome series of pathogen examples isolated from individuals across countries, which indicate hereditary diversity and advancement from the pathogen (Phan, 2020b). Hereditary evaluation of 103 genomes offers indicated that SARS-CoV-2 offers progressed into two main types, specified as L and S. The L-type can be more prevalent, within about 70% from the instances in Wuhan (Tang et al., 2020). 3.2. Settings of transmitting In the initial stage from the epidemic, as 55% from the individuals were linked to a sea food and wet pet market, a most likely zoonotic source was recommended (Sunlight et al., 2020). Studies possess indicated that SARS-CoV-2 offers close structural resemblance with bat coronaviruses, assisting the idea that SARS-CoV-2.