A sixty-two-year-old male individual underwent orchiectomy and was diagnosed with diffuse large B-cell lymphoma in the testicle and spermatic cord. 18F-FDG PET/BT tetkikinde, hipermetabolik ?zellikte ?ok say?da lenfadenopatiler, akci?er lezyonlar?, b?breklerde ve srrenal bezlerde kitle lezyonlar? saptand?. Ek olarak, sa? testiste, prostat bezinde ve sol testikler vende lenfoma tutulumu ile uyumlu diffz ?zellikte artm?? 18F-FDG tutulu?u izlendi. Lenfomada rogenital sistem nadir ekstranodal tutulum yerlerinden biri olup bu olgu bildi?imiz kadar?yla tm rogenital sistem yap?lar?nda artm?? 18F-FDG tutulumu g?steren lezyonlar izlenen literatrdeki ilk olgudur. ? Open in a separate window Figure 1 A sixty-two-year-older male patient suffering from swelling of the remaining testicle underwent orchiectomy and was diagnosed with diffuse large B-cell lymphoma in the testicle and spermatic cord. A) Maximum intensity projection image of the staging-meant 18F-FDG OSI-420 supplier positron-emission tomography/computed tomography (PET/CT) scan of the case exposed multiple hyper-metabolic lymphadenopathies in the cervical, thoracic and abdominopelvic regions (SUVmax: 34.8), hyper-metabolic lesions consistent with lymphatic/parenchymal infiltration in the lungs (SUVmax: 16.4-45.2), pleural involvements accompanied by rib invasion on the right thorax (SUVmax: 29.2), along with lymphoma infiltration of bilateral adrenal glands (SUVmax: 38.7-56.5), the kidneys (SUVmax: 40-53), the prostate gland (SUVmax: 40.4), the right testicle (SUVmax: 20.8) and the left testicular vein. B) Mass lesions in the kidneys are seen in selected coronal CT and fused PET/CT images. Open in a separate window Figure 2 At sagittal CT and fused PET/CT images (A); mass lesion at the remaining adrenal gland (A; black arrow) and intense 18F-FDG uptake (SUVmax: 36.8) along the left testicular vein (A; white arrow) are observed. OSI-420 supplier At transaxial CT and fused PET/CT images (B, C); diffuse improved 18F-FDG uptake without size or density changes at CT image suggesting diffuse lymphomatous infiltration on prostate (SUVmax: 40.4) (B) and ideal testicle (SUVmax: 20.8) (C) are also seen. Although lymphomas generally originate from lymph nodes or lymphoid tissue, extranodal sites can also be involved. Extranodal lymphomas can occur in nearly every organ. The most typical extranodal involvement sites are OSI-420 supplier gastrointestinal program, central nervous program, skin, Waldeyers band, spleen and even more seldom kidneys, testicle, feminine genital organs and liver (1,2). The genitourinary program can be an extremely uncommon extranodal infiltration region in lymphomas, the regularity is %1-2 for testicle and significantly less than %1 for kidney, and the dominant histological subtype is normally diffuse B-cellular lymphoma (1,3). To the very best of our understanding this is actually the initial case in the literature having 18F-FDG accumulating lesions on all the structures of the genitourinary program. CT, the most typical imaging modality at medical diagnosis and follow-up, is founded on identifying the size and the form of lymphomatous lesions and their user interface with adjacent structures. Identification of disease in normal-sized organs is normally tough by anatomical imaging modalities. At this stage the usefulness of the useful information supplied by 18F-FDG Family pet/CT comes forwards (2,4,5). Going back decades, 18F-FDG Family pet/CT provides been trusted for disease staging, recurrence recognition, and monitoring treatment response in sufferers with Hodgkins disease and non-Hodgkin lymphoma (4,5,6,7). 18F-FDG Family pet/CT with unenhanced CT is normally even more sensitive and particular than contrast-improved CT for the recognition of extralymphatic lymphomatous involvement (7). Also, 18F-FDG Family pet/CT is more advanced than CT for identifying diffuse lymphomatous infiltration in organs (8). In cases like this display, despite urinary excretion of 18F-FDG, it really Col4a5 is verified that 18F-FDG Family pet/CT is more advanced than CT in identifying genitourinary program involvement of lymphoma, specifically in diffuse lymphomatous infiltration. Footnotes Ethics Informed Consent: The topic in the analysis provided written educated consent. Peer-review: Externally peer-examined. Contributed by Authorship Contributions Medical and Medical Procedures: A.O., ?.?., Idea: A.O., B.Y., Style: A.O., B.Y., Data Collection or Processing: A.O., Evaluation or Interpretation: A.O.,.