Objective The purpose of this study was to evaluate the occurrence rate of diffusion positive lesions (DPLs), and to assess the peri-procedural risk factors for the occurrence of DPLs in patients who underwent coil embolization of cerebral aneurysms. to increase in ruptured aneurysms compared with unruptured aneurysms (57% vs. 43%, = 0.077). Logistic regression analysis revealed that age > 55 years was the only independent risk element for the event of DPLs. Summary DPLs occured more frequently in ruptured aneurysm and at an older age. Although most DPLs are asymptomatic, careful Echinatin manipulation of cerebral or extracerebral arteries using numerous endovascular devices is definitely important to reducing the event of DPLs. BAC appeared to reduce event of TE events in patient with unruptured aneurysm. value < 0.05 was considered statistically significant. RESULTS Sixty five of the 100 individuals with ruptured aneurysms were ladies. Anterior cerebral artery (ACA) aneurysms were most common followed by internal carotid artery (ICA) aneurysms, posterior blood circulation aneurysms and middle cerebral artery (MCA) aneurysms. The techniques utilized for coiling were BAC in 22, SAC in eight, and simple coiling only in 70. Mean packing denseness was 37.1%. Total obliteration of the aneurysm was accomplished in 68%, neck remnant in 23% and aneurysm sac filling in 8%. Seventy one of 86 unruptured aneurysms were in women. The location of aneurysms was ICA in 41, ACA in 21, posterior blood circulation in 14, and MCA in 10. The techniques utilized for coiling were BAC in 17, SAC in 43, and simple coiling in 26. Mean packing denseness was 35.8%. Total obliteration of the aneurysm was accomplished in 54.7%, neck remnant in 23.3% and aneurysm sac filling in 22.1%. Even though there were 14 intra-procedural ruptures and 8 intra-procedural TE complications, the permanent complication rate was only 2.1% (4/186) (Table 1). Table 1 Summary of medical characteristics relating to ruptured and unruptured aneurysms in 186 individuals Overall, DPLs were observed in 50.5% (94/186). DPLs Rabbit polyclonal to CD105 experienced a tendency to increase in ruptured aneurysms compared with unruptured aneurysms (57% vs. 43%, = 0.077). The mean quantity of DPLs was significantly higher in the ruptured group Echinatin (3.22 5.22, range: 0-30) than in the unruptured group (1.77 3.46, range: 0-16) (= 0.025) (Table 1). Increasing age influenced the event of DPLs in individuals with ruptured aneurysms, however, the difference did not reach statistical significance (= 0.056) (Table 2). ACA aneurysms showed the highest incidence of DPLs, followed by ICA aneurysms, but the difference was not statistically significant (> 0.05). Endovascular neurosurgeon’s encounter did not impact the event of DPLs in both organizations even though the initial period (before yr 2010) showed high incidence of DPLs (Table 2). Table 2 Incidence of diffusion positive lesions according to the medical characteristics in individuals with ruptured and unruptured Echinatin aneurysms Aneurysm selection was regarded as hard in 21.0%. However, the event of DPLs was not dependent on the difficulty of aneurysm selection. Aneurysm size, neck size and element percentage did not influence the event of DPLs. The left part approach showed more DPL in all anterior blood circulation aneurysms (n = 160), however, the difference was not statistically significant (> 0.05) (Table 2). Based on the coiling technique, DPLs occurred in 23.5% of BAC, 41.9% of SAC and 57.7% of simple coiling in unruptured aneurysms (= 0.08). However, in individuals with ruptured aneurysms, event of DPLs did not differ among simple coiling (54.3%), SAC (62.5%), and BAC (63.6%) organizations (= 0.71) (Table 2). Mean quantity of DPLs was the highest in the SAC group (5.25), followed by BAC (3.41) and Echinatin simple coiling group (2.93) in ruptured aneurysms. However, the BAC group showed the lowest mean quantity of DPLs (1.18) in unruptured aneurysms (Fig. 2). In comparison of simple coiling and BAC in unruptured aneurysm individuals, the event of DPLs was significantly reduced BAC (= 0.034), however, there was no difference in ruptured aneurysm individuals (= 0.472) (Fig. 3). Fig. 2 Pub graphs showing the mean quantity of diffusion positive lesions (DPLs) according to the treatment modalities. Mean quantity of DPL was the highest in stent aided coiling followed.