Case Contrast moderate\induced transient leukopenia is very rare. leukopenia.1, 2 Agranulocytosis is a life\threating condition that occurs due to decreased absolute neutrophil counts of 500/L.3 Here, we report a case of a 73\year\old man diagnosed with contrast media\induced transient leukopenia. Case At 10:08 am, a 73\year\old\man underwent an abdominal contrast\enhanced computed tomography (CT) scan using non\ionic iodinated contrast medium, as a follow\up procedure for chronic pancreatitis. The procedure was completed uneventfully and the CT showed no significant findings. One hour after the procedure, he was admitted to the emergency department for chest discomfort. The patient had a medical history of chronic pancreatitis and allergy to a different contrast medium with symptoms of only nausea that occurred 6?years ago. Thus, we changed the contrast medium and used them 10 times. No symptoms occurred before the present case. The patient’s initial findings were: height, 173?cm; weight, 77.0?kg; blood pressure, 83/52?mmHg; heart rate, 40?b.p.m.; temperature, 36.1C; respiratory rate, 18/min; SpO2, 98% with oxygen delivered through a face mask (5?L/min); and a Glasgow Coma Scale rating of E3V5M6. A physical exam revealed regular bilateral Slc7a7 air Fasudil HCl inhibitor database admittance without the wheezing or rhonchi. The full total results of his cardiovascular and neurological examinations were normal. His belly on examination made an appearance normal and didn’t show any pores and skin eruptions. The medical course of the individual is demonstrated in Fig.?1. Open up in another window Shape 1 Clinical span of a 73\yr\old guy with comparison press\induced transient leukopenia. The shape depicts adjustments in the patient’s white bloodstream cell count number (WBC), total neutrophil count number, and body’s temperature over time. WBC count was decreased. A fever was had by The individual temp of 38.9C at 4?h after entrance to the crisis department (ED). His WBC count improved. The individual was discharged 2?times later on. KT, k?rpertemperatur; PCT, procalcitonin. The lab findings are demonstrated in Desk?1. Both chest and electrocardiogram X\ray didn’t expose any significant findings. The patient’s total white bloodstream cell, neutrophil, and lymphocyte matters had been 930, 232, and 678/L, respectively (Fig.?2A). His hemoglobin platelet and amounts matters were normal. Primarily, anaphylaxis was suspected because of his health background and cardiovascular symptoms. Therefore, the patient was presented with 5?mg chlorpheniramine malcinic acidity, 20?mg famotidine, and 125?mg methylprednisolone, and admitted to a healthcare facility for follow\up. Open up in another window Fasudil HCl inhibitor database Shape 2 HematoxylinCeosin staining (10) of peripheral bloodstream cells from a 73\yr\old guy with comparison press\induced transient leukopenia. A, Neutrophils aren’t within the peripheral bloodstream in the proper period of entrance towards the crisis division. B, Regular neutrophils can be found in the peripheral bloodstream 12?days later on. Table 1 Lab testing of the 73\yr\old guy with comparison press\induced transient leukopenia at entrance to the crisis division (ED), 1?day time before entrance, and 12?times after entrance thead valign=”best” th align=”still left” valign=”best” rowspan=”1″ colspan=”1″ /th th align=”still left” valign=”best” rowspan=”1″ colspan=”1″ ?1?day time /th th align=”remaining” valign=”best” rowspan=”1″ colspan=”1″ ED /th th align=”remaining” valign=”best” rowspan=”1″ colspan=”1″ +12?days /th /thead Peripheral bloodRed blood cells, 104/L398?370395Hemoglobin, g/dL13.7?14.013.9Hematocrit, %41.039.540.1Platelets, 104/L14.513.117.8White blood cells, /L4,6909305,050Band, %ND1.052.9Segmented, %ND24.01.8Eosinophils, %ND1.01.8Basophils, %ND0.00.6Monocytes, %ND1.07.1Lymphocytes, %ND73.037.6Blood chemistryTotal protein, g/dL7.16.37.0Albumin, g/dL4.53.94.2Urea nitrogen, mg/dL9.210.511.2Creatinine, mg/dL0.830.850.89Aspartate aminotransferase, IU/L232220Alanine aminotransferase, IU/L212223Total bilirubin, mg/dLND1.11.4Alkaline phosphatase, IU/LND168175Lactic acid dehydrogenase, U/LND163155Sodium, mEq/L141137140Potassium, mEq/L3.73.94.2Chloride, mEq/L105105106Glucose, mg/dL126165140Serological testC\reactive protein test, mg/dLND0.040.15Coagulation Prothrombin time, sND11.511.9Activated partial thromboplastin time, sND23.230.8D\dimer, g/mLND7.30.5IL\6, pg/mLND2.9NDTNF\, pg/mLND0.97NDAnti\neutrophil antibodiesNDNegativeND Open in a separate window IL\6, interleukin\6; TNF\, tumor necrosis factor\; ND, not done laboratory finding. Shortly after admission, the patient complained of chills and had a temperature of 37.6C. His total white blood cell count was 1,160/L and the neutrophil count was 557/L. Approximately 2? h after admission the patient developed a fever and his body temperature was 38.9C. We obtained samples of bloodstream, sputum, and urine for tradition. Subsequent entire\body CT scans and a upper body X\rays didn’t reveal any disease foci. The individual was identified as having neutropenic fever and treated with cefepime. At 3:00?am the very next day, his temperatures returned on track. In addition, his white blood vessels cell rely got retrieved. Microbial culture outcomes were adverse for infection. As a result, we diagnosed the individual with idiosyncratic transient leukopenia that was induced from the comparison moderate. Interleukin\6, tumor necrosis element\ (TNF\), and anti\neutrophil antibody results were unremarkable. The health of the individual improved on Fasudil HCl inhibitor database day time two after hospitalization and he was discharged (Fig.?2B). The individual has not skilled a recurrence in the 1?season since this event. Dialogue You can find few reviews of comparison medium\induced severe leukopenia. We undertook an intensive search of released function using PubMed.